How to run Disk Defragmenter in Windows Vista By Drew Mathers | October 23, 2015 1 1. Click: Start 2 2. Click: All Programs 3 3. Click: Accessories 4 4. Click: System Tools 5 5. Click: Disk Defragmenter 6 6. Click: Continue 7 7. Click: Defragment now 8 8. Click: OK 9 9. Click: Close (process will continue) 10 Posted in Supplemental